4 dispatches
Immune cell therapies like CAR-T continue to provide some nearly miraculous therapeutic power. In addition to handling solid tumors, it turns out CAR-T can also be used to treat autoimmune disorders like lupus, rheumatoid arthritis, and ulcerative colitis. By engineering CAR-T cells to attack B-cells, the body’s factories for the autoantibodies that do the damage in an...
The promise of immune cell therapies is to direct the incredible sophistication of the immune system to the medical targets we want to hit. In the case of CAR-T cells, we take a patient’s own immune T-cells and “program” them through genetic modification to go after cancer cells. While the process of the genetic modification to create those cells is still incredibly expensive...
Immune cell therapy — the use of modified immune cells directly to control cancer and autoimmune disease — has shown incredible results in liquid tumors (cancers of the blood and bone marrow like lymphoma, leukemia, etc), but has stumbled in addressing solid tumors. Iovance, which recently had its drug lifileucel approved by the FDA to treat advanced melanoma, has demonstrated...
Gene editing makes possible new therapies and actual cures (not just treatments) that were previously not. But, one thing that doesn’t get discussed a great deal is how these new gene editing-based therapies throw the “take two and call me in the morning” model out the window. This interesting piece in BioPharmaDive gives a fascinating look at all the steps for a gene editing...