• Essay
Real World Effectiveness vs. Clinical Trial Efficacy
Randomized controlled trials (RCTs) are the “gold standard” in healthcare for proving a treatment works. And for good reason. A well-designed and well-powered (i.e., large enough) clinical trial establishes what is really due to a treatment as opposed to another factor (e.g., luck, reversion to the mean, patient selection, etc.), and it’s a good thing that drug regulation is...